Overdose hydroxyzine

Overdose. Withdrawal and dependence. Expiration. What is hydroxyzine? Hydroxyzine is a generic prescription medication. It’s approved by the Food and Drug Administration (FDA) for the...

Overdose hydroxyzine. Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses).

Overdose Information for Atarax. The most common manifestation of hydroxyzine hydrochloride overdosage is hypersedation. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken. If vomiting has not occurred spontaneously, it should be induced. Immediate …

Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose. There is no specific antidote. It is doubtful that hemodialysis would be of any value in the treatment of overdosage with hydroxyzine. dizziness. fainting. fast heartbeat. hives, itching, or skin rash. irregular or slow heart rate. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. trouble breathing. unusual tiredness or weakness. Get emergency help immediately if any of the following symptoms of overdose occur: Hydroxyzine is a first-generation histamine H 1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties. It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.CLINICAL FEATURES OF OVERDOSE. Signs of severe toxicity; Range of peripheral and central signs of toxicity; Chronic toxicity; LABORATORY EVALUATION; DIFFERENTIAL DIAGNOSIS; DIAGNOSIS; MANAGEMENT. Airway, breathing, circulation, monitoring; Cardiotoxicity; Agitation, seizures, hyperthermia; Decontamination; Antidotal therapy with physostigmine ...Hypotension, though unlikely, may be controlled with intravenous fluids and levarterenol or metaraminol. Do not use epinephrine as hydroxyzine counteracts its pressor action. Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose. There is no specific antidote.It is possible to overdose on penicillin. Taking more than the recommended dosage of the antibiotic, which is commonly used to treat bacterial infections like ear infections and re... Hydroxyzine is also used along with other medications in adults and children as a sedative before and after general anesthesia for surgery. Hydroxyzine is in a class of medications called antihistamines. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. It also works by decreasing activity in ...

Contraindicated. hydroxyzine + pimozide. contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects) potassium chloride.Mar 11, 2020 · Taking too much Hydroxyzine can result in a range of signs and symptoms that may appear in different areas of the body. The symptoms of an overdose differ from the common side effects of taking the drug. Oct 31, 2023 ... Hydroxyzine, marketed as Vistaril or Atarax, is an antihistamine ... Symptoms of a hydroxyzine overdose may include: Extreme sleepiness ... Contraindicated. hydroxyzine + pimozide. contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, anticholinergic adverse effects (additive effects) potassium chloride. A severe hydroxyzine overdose should be considered a medical emergency, and you should call 911 or go to the nearest emergency room immediately. The lowdown. Hydroxyzine can have a sedative effect and help you sleep. However, it is not typically prescribed to treat primary insomnia. It may be used to treat anxiety, which can …

Dilated pupils are the classic symptom of a hydroxyzine overdose. Below are other symptoms of a hydroxyzine overdose in different parts of the body. AIRWAYS AND LUNGS. Shortness of breath; BLADDER AND KIDNEYS. Difficulty urinating; EYES, EARS, NOSE, THROAT, AND MOUTH. Blurred vision; Dry mouth; Enlarged pupils; Dry eyes; Ringing in the ears ...Hydroxyzine is intended for the symptomatic treatment of anxiety and stress associated with neurosis as well as with conditions of organic illness. This drug has muscle relaxant, antihistimine, analgesic, local anesthetic, and antiemetic action as well as a wide therapeutic effect. ... or were associated with intentional overdose. These results ...Of the overdose cases, 1 was previously reported (25), 1 was attributed to primary olanzapine toxicity (27) (blood concentration 520 ng/mL) and 1 was due to combined bupropion and fluoxetine toxicity, also previously reported (12). Malignant hyperpyrexia was reported as the cause of death in an overdose of olanzapine (150 mg) and …Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. …Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose. There is no specific antidote. It is doubtful that hemodialysis would be of any value in the treatment of overdosage with hydroxyzine.

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It is possible to overdose on penicillin. Taking more than the recommended dosage of the antibiotic, which is commonly used to treat bacterial infections like ear infections and re...Caffeine and Sodium Benzoate Injection, USP, may be used to counteract central nervous system depressant effects. Hydroxyzine overdose may cause QT prolongation ...CLINICAL FEATURES OF OVERDOSE. Signs of severe toxicity; Range of peripheral and central signs of toxicity; Chronic toxicity; LABORATORY EVALUATION; DIFFERENTIAL DIAGNOSIS; DIAGNOSIS; MANAGEMENT. Airway, breathing, circulation, monitoring; Cardiotoxicity; Agitation, seizures, hyperthermia; Decontamination; Antidotal therapy with physostigmine ...At Addiction Group, we believe knowledge is power - and in the realm of addiction recovery, it's also hope, direction, and potential for healing. A foundational part of our mission is to not just harness data, but to share it generously. By making critical addiction data accessible, we empower communities, individuals, and professionals to make ...

Hydroxyzine is primarily used for dogs to treat allergies and allergic reactions, such as those related to snake or insect bites and vaccines. The drug is an anti-inflammatory, which can open ...Hydroxyzine (Ingredient) Chemical formula: C21H27ClN2O2 Drugbank ID: DB00557 ATC codes: N05BB51, N05BB01. The information below refers to products available in the United States that contain hydroxyzine. Products containing hydroxyzine hydroxyzine systemic. Brand names: Atarax, Vistaril, Hyzine, Vistazine, RezineAug 15, 2023 · It takes about five half-lives for a medication dose to leave the body. The half-life of both forms of hydroxyzine ranges from 14 to 25 hours. Thus, the medication can remain in the body for about 70 to 125 hours (five half-lives) after the last dose. However, the effects of a dose may only last up to about six hours. In case of emergency/overdose. What other information should I know? Brand names. Why is this medication prescribed? Hydroxyzine is used in adults and children to relieve …Hydroxyzine is approved for pre- and postpartum adjunctive therapy to control emesis, reduce opioid dosage, and treat anxiety. However, use in early pregnancy is contraindicated by the manufacturer and other agents are recommended for the treatment of nausea and vomiting of pregnancy (ACOG 189 2018). Hydroxyzine may be used as an …Hydroxyzine is available as a generic drug and under the brand names Atarax and Vistaril. The common dosage for hydroxyzine depends on the reason it is prescribed: Anxiety: 50-100 mg, four times per day; Skin reactions: 25 mg, 3-4 times per day; Allergies: 25 mg, 3-4 times per dayAug 28, 2023 ... Additionally, snorting hydroxyzine can result in an overdose, which can have potentially lethal side effects such as convulsions, respiratory ...Jul 29, 2021 · Alprazolam is a benzodiazepine and belongs to the same family as lorazepam (Ativan) and clonazepam (Klonopin). This medication is FDA-approved to treat anxiety disorders (including GAD) and panic disorder. As with hydroxyzine, alprazolam is intended for short-term use — up to 4 months for anxiety disorders and up to 10 weeks for panic disorder. The biggest risk of hydroxyzine for dogs is an overdose. Signs of an overdose of hydroxyzine include: Excessive sleepiness. Hyperexcitability. Loss of coordination or stumbling. Increased body temperature. Passing out. Seizures If you know or suspect your dog has overdosed on hydroxyzine, contact your veterinarian immediately …Hydroxyzine (brand names Vistaril, Atarax) is a first-generation antihistamine of the diphenylmethane and piperazine class. It was initially synthesized in 1956 and thereafter marketed in the U.S. by the pharmaceutical juggernaut, Pfizer. Although a relatively ancient medication by today’s standards, hydroxyzine is still commonly prescribed ...As hydroxyzine is also a first generation antihistamine, it too can make a person sleepy and is typically dosed 3 times daily. It's just another option if everything you have tried thus far has been ineffective. Finally, we mentioned at the beginning of the article that H1 receptors are mainly responsible for allergy symptoms. There is however ...

CONCLUSIONS: Hydroxyzine is a safe and effective drug, but life-threatening adverse effects can occur with overdose. Symptoms of toxicity are delirium, seizures, tachycardia, and hypotension. High dose of hydroxyzine may cause ARDS and distributive shock. A postmortem analysis of a confirmed hydroxyzine overdose demonstrated severe …

Editor’s Note: If you or someone you know is living with an opioid addiction or another substance use disorder, know that help is available. Narcan, also known as Naloxone, is an F...Available as hydroxyzine pamoate and hydroxyzine hydrochloride; dosage expressed in terms of the hydrochloride. Use the smallest possible effective dosage. Pediatric Patients Anxiety Oral. Children <6 years of age: 50 mg daily given in divided doses. Children ≥6 years of age: 50–100 mg daily given in divided doses. Pruritus OralOverdose; FAQ; Uses of Hydroxyzine Capsules and Tablets: It is used to treat itching. It is used to treat anxiety. It is used to put you to sleep for surgery. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Hydroxyzine Capsules and Tablets? If you have an allergy to …What Is Hydroxyzine And What Does It Treat? Hydroxyzine is an antihistamine. It is approved for the treatment of anxiety. However, hydroxyzine is also used to treat difficulty sleeping, nausea, vomiting, itching, skin rash, and allergies. Symptoms of anxiety include: Feeling nervous. Feeling fearful. Excessive worrying. Difficulty sleeping.Overdose; FAQ; Uses of Hydroxyzine Capsules and Tablets: It is used to treat itching. It is used to treat anxiety. It is used to put you to sleep for surgery. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Hydroxyzine Capsules and Tablets?I've overdosed a lot. It depends on how much you take, and how weak your immune system is, and also their toxicity. Seroquel won't work, it's extremely low toxicity. At least that's what I was told. (I overdosed on over 88 of them when I was younger). 2. Prestigious-Recipe-4. • 3 yr. ago. yes i wanna know too for research purposes only of course.A hydroxyzine overdose can happen to anybody who uses the drug incorrectly, either by mistake or due to willful ignorance. It is often a sign that an individual has been abusing the substance and has been forced to take higher and higher doses. Taking higher doses occurs with many drugs due to a built-up tolerance or a desire for a more potent ...Overdose Information for Atarax. The most common manifestation of hydroxyzine hydrochloride overdosage is hypersedation. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken. If vomiting has not occurred spontaneously, it should be induced. Immediate gastric lavage is also ...fatigue. weakness. low blood pressure. headache*. dry mouth *. mild allergic reaction *. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer ...

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Hypotension, though unlikely, may be controlled with intravenous fluids and levarterenol or metaraminol. Do not use epinephrine as hydroxyzine counteracts its pressor action. Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose. There is no specific antidote.a seizure (convulsions). Side effects such as drowsiness and confusion may be more likely in older adults. Common hydroxyzine side effects may include: drowsiness; headache; dry mouth; or. skin rash. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.hydroxyzine (Vistaril) promethazine (Promethegan) ... If an overdose happens, seek immediate medical attention or call the AAPCC at 800-222-1222. Last medically reviewed on April 21, 2020.Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses).Introduction: Exposures to hydroxyzine, a first-generation H1 antihistamine, have increased rapidly over the last two decades. Many assumptions about hydroxyzine poisoning are based on other ...Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. ... Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose. Decreased awareness or responsiveness …Side effects associated with use of Hydroxyzine, include the following: Dry mouth. Drowsiness (usually transitory and may disappear in a few days of continued therapy or upon reduction of the dose) Involuntary motor activity ( tremor, convulsions) usually with doses considerably higher than those recommended.Dec 17, 2022 · Hydroxyzine is a type of drug called an antihistamine. It works by attaching to histamine receptors (binding sites) in your body. This produces a calming effect that helps relieve anxiety and ... It is possible to overdose on penicillin. Taking more than the recommended dosage of the antibiotic, which is commonly used to treat bacterial infections like ear infections and re...Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses).Overdose. Withdrawal and dependence. Expiration. What is hydroxyzine? Hydroxyzine is a generic prescription medication. It’s approved by the Food and Drug Administration (FDA) for the... ….

If you do, we would love to answer them for you. Please contact us today by calling 888.450.2153. Prescription drug addiction is a serious problem across the country. Call 425.532.3396 to learn about how a prescription drug rehab center can help with recovery.Hypotension, though unlikely, may be controlled with intravenous fluids and levarterenol or metaraminol. Do not use epinephrine as hydroxyzine counteracts its pressor action. Hydroxyzine overdose may cause QT prolongation and Torsade de Pointes. ECG monitoring is recommended in cases of hydroxyzine overdose. There is no specific antidote.Drugs with anticholinergic action are widely prescribed in the elderly population due to their potential clinical benefits. However, these benefits are limited by adverse effects which may be serious in particular circumstances. This review presents different aspects of the use of anticholinergics in old age with a focus in psychogeriatric ...Applies to: oxycodone and hydroxyzine. Using narcotic pain or cough medications together with other medications that also cause central nervous system depression can lead to serious side effects including profound sedation, respiratory distress, coma, and even death. Talk to your doctor if you have any questions or concerns.Table of contents. Can You Overdose on Hydroxyzine? Hydroxyzine Overdose Side Effects. Hydroxyzine Toxicity. What to do if Someone Overdosed on …Overdose. Uses. Hydroxyzine is used to treat itching caused by allergies. It is an antihistamine and works by blocking a certain natural substance ( histamine) that your body makes during an...What Is Hydroxyzine And What Does It Treat? Hydroxyzine is an antihistamine. It is approved for the treatment of anxiety. However, hydroxyzine is also used to treat …Overdose Information for Atarax. The most common manifestation of hydroxyzine hydrochloride overdosage is hypersedation. As in the management of overdosage with any drug, it should be borne in mind that multiple agents may have been taken. If vomiting has not occurred spontaneously, it should be induced. Immediate gastric lavage is also ...dizziness. fainting. fast heartbeat. hives, itching, or skin rash. irregular or slow heart rate. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. trouble breathing. unusual tiredness or weakness. Get emergency help immediately if any of the following symptoms of overdose occur:A hydroxyzine overdose can happen to anybody who uses the drug incorrectly, either by mistake or due to willful ignorance. It is often a sign that an individual has been abusing the substance and has been forced to take higher and higher doses. Taking higher doses occurs with many drugs due to a built-up tolerance or a desire for a more potent ... Overdose hydroxyzine, Antihistamines are medicines often used to relieve symptoms of allergies, such as hay fever, hives, conjunctivitis and reactions to insect bites or stings. They're also sometimes used to prevent motion sickness, to treat feeling sick (nausea) or being sick (), and as a short-term treatment for insomnia. Most antihistamines can be bought from pharmacies …, Overdose from hydroxyzine is most commonly characterized by hypersedation, but may also manifest as convulsions, stupor, nausea, and vomiting. 18 In cases of overdose, consider the induction of vomiting and the use of gastric lavage. Other treatment should involve general symptomatic and supportive care. Hypotension may be controlled by ..., Apr 12, 2021 · core elements of the anticholinergic toxidrome. Key elements in the toxidrome are: Dilated pupils. Delirium. Tachycardia. Dry skin – This is an essential element, which helps separate anticholinergic toxidromes from sympathomimetic toxidromes. These four elements suggest an anticholinergic toxidrome. , Mar 21, 2024 ... The indicators of Hydroxyzine abuse closely mirror those of overdose, and the same applies to Hydroxyzine addiction. Here are some of the ..., Aug 28, 2023 ... Additionally, snorting hydroxyzine can result in an overdose, which can have potentially lethal side effects such as convulsions, respiratory ..., Hydroxyzine may cause a condition that affects the heart rhythm ... Overdose . If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call ..., Hydroxyzine is used to help control anxiety and tension caused by nervous and emotional conditions. It can also be used to help control anxiety and produce sleep before surgery. This medicine is also used to relieve symptoms of allergic conditions (eg, chronic urticaria and atopic and contact dermatoses). Hydroxyzine is an antihistamine., Overdose from hydroxyzine is most commonly characterized by hypersedation, but may also manifest as convulsions, stupor, nausea, and vomiting. 18 In cases of overdose, consider the induction of vomiting and the use of gastric lavage. Other treatment should involve general symptomatic and supportive care. , Dec 17, 2022 · Hydroxyzine oral tablet is a prescription drug that treats anxiety, among other uses. ... Mild symptoms of an overdose of hydroxyzine can include: nausea and vomiting; tachycardia (fast heartbeat) , Nov 16, 2023 ... Vistaril (hydroxyzine pamoate) is used to treat anxiety symptoms ... If Vistaril overdose is suspected, immediate medical care is critical., Anticholinergic toxicity is common in the emergency department but rarely fatal.[1] According to the 2015 annual American Association of Poison Control Centers (AAPCC) report, there were just under 14,000 exposures reported to poison control centers that year, none of which lead to mortality.[1] However, in prior years, up to 51 cases have been reported as deadly.[2][3][4] Overdoses of ..., Hydroxyzine starts to work in about 15 to 30 minutes but its drowsy effect may last for 4 to 6 hours. Hydroxyzine can reduce itching and redness due to allergy skin tests for up to 4 days. Hydroxyzine is used to relieve anxiety, itching due to allergies, and as a premedication prior to surgery., Feb 15, 2017 ... Hydroxyzine: learn about side effects ... Hydroxyzine. pronounced as (hye drox' i zeen). Email ... In case of emergency/overdose. Expand Section., Overdose. Too much hydroxyzine and/or alcohol can put an individual at risk for a drug overdose. The most common symptom of this kind of overdose is ..., Overdose. Too much hydroxyzine and/or alcohol can put an individual at risk for a drug overdose. The most common symptom of this kind of overdose is ..., fatigue (low energy) headache*. insomnia (trouble falling and staying asleep) dizziness. dry mouth *. confusion. constipation*. mild allergic reaction *. * To learn more about this side effect ..., Dosing: Adult. Antiemetic: IM: 25 to 100 mg/dose. Anxiety: Oral: Manufacturer’s labeling: 50 to 100 mg 4 times daily. Alternative recommendations (off-label dosing): 37.5 to 75 mg daily in divided doses (WFSBP [Bandelow 2008]; WFSBP [Bandelow 2012]) IM: Initial: 50 to 100 mg, then every 4 to 6 hours as needed. , Hydroxyzine is also used along with other medications in adults and children as a sedative before and after general anesthesia for surgery. Hydroxyzine is in a class of medications called antihistamines. It works by blocking the action of histamine a substance in the body that causes allergic symptoms. It also works by decreasing activity in ..., Anticholinergic toxicity is frequently encountered in the emergency department, and thus, it is essential that emergency clinicians be familiar with this toxidrome. There are approximately 8000 to 10,000 exposures to anticholinergic substances (including plants, drugs, and antispasmodics) reported to United States Poison Centers annually [ 1 …, dizziness. fainting. fast heartbeat. hives, itching, or skin rash. irregular or slow heart rate. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. trouble breathing. unusual tiredness or weakness. Get emergency help immediately if any of the following symptoms of overdose occur:, Ziprasidone. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adagrasib. Alfentanil. Alfuzosin. Alprazolam. Amantadine. , First Aid tips for Hydroxyzine Overdose: Hydroxyzine Overdose can be a life-threatening condition. If someone is suspected to have overdosed on hydroxyzine, call 911 (or your local emergency number) for emergency assistance immediately. Call the Poison Control Center at 1-800-222-1222 (or the local poison control center) for further ..., Unisom (doxylamine) Prescription first-generation H1-antihistamines sometimes used for the treatment of nasal allergies (generally when other allergy symptoms accompany) include: Atarax (hydroxyzine) Dimetane (brompherniramine) Palgic (carbinoxamine) Each of these medications has generic versions and may be found …, We need you! See something you could improve? Make an edit and help make WikEM better for everyone., Among cases that described the TTO, 15 were reported following an overdose of hydroxyzine and patients experienced adverse events within 1 day. Excluding these 15 reports of overdose, the median TTO was 3 days. Overall, 14 out of the 59 cases (excluding cases with overdose) had a TTO of <7 days; considered a sufficiently long …, Hydroxyzine is not considered habit-forming or prone to withdrawal upon discontinuation, but it can be very dangerous in the setting of overdose. Besides drowsiness and nausea, an overdose of hydroxyzine can lead to seizures or respiratory depression. An overdose of this drug can be a medical emergency that should prompt a …, Muscle relaxants have a sedative effect, and when consumed in large doses, they create a buzz, a euphoric feeling, improve mood and bring on pleasant misperceptions, according to S..., I've overdosed a lot. It depends on how much you take, and how weak your immune system is, and also their toxicity. Seroquel won't work, it's extremely low toxicity. At least that's what I was told. (I overdosed on over 88 of them when I was younger). 2. Prestigious-Recipe-4. • 3 yr. ago. yes i wanna know too for research purposes only of course., Hydroxyzine is an antihistamine medication that treats the symptoms of allergies and allergic reactions It works by blocking histamine., Mar 13, 2024 · Usual Adult Dose for Sedation. Oral: 50 to 100 mg orally ONCE. Parenteral: 25 to 100 mg IM ONCE. Comment: This drug may potentiate barbiturates and/or meperidine. Uses: Oral: As a sedative when used as premedication or following general anesthesia. Pre-anesthetic adjunctive treatment. Parenteral: , Tablets. Hydroxyzine belongs to a group of medicines known as sedating antihistamines. It is used to relieve itching caused by some skin conditions, such as nettle rash ( urticaria ). Exposure to substances such as pollen, pet fur, house dust or insect bites can cause some people to produce an excess of a chemical called histamine., Anticholinergic toxicity is common in the emergency department but rarely fatal.[1] According to the 2015 annual American Association of Poison Control Centers (AAPCC) report, there were just under 14,000 exposures reported to poison control centers that year, none of which lead to mortality.[1] However, in prior years, up to 51 cases have …, Dec 30, 2020 · Hydroxyzine can also relieve itching due to hives, allergic reactions, or atopic dermatitis. Hydroxyzine injections are used to relieve nausea and vomiting. Finally, doctors also use hydroxyzine HCl as a sedative before medical procedures or following general anesthesia. What form(s) does Hydroxyzine Hcl come in. Tablet. 10 mg. 25 mg. 50 mg